ExpreS2ion Biotech (One-pager): Early stage biotech company with a phase 3 validated platform
Although not a one-product company, the huge shareholder value creation lies in the progression of its ES2B-C001 breast cancer vaccine candidate, given its unmet need within HER2+ breast cancer therapy, and very large addressable market at around USD 10bn annually based on current treatments.
The ES2B-C001 vaccine targets the HER2+ protein, associated with a more aggressive, higher recurrence, and higher mortality rate disease. The ES2B-C001 vaccine targets multiple HER2+ epitope sites vs existing therapies (1-2 epitopes) of the HER2-ECD. Existing monoclonal therapies have been associated with resistance, (which pre-clinical data has overcome), and additional adverse cardiac effects. An elongation of progression free survival (PFS) or reduced cardiac effects would offer a significant advantage.
The breast cancer vaccine candidate ES2B-C001 offers two notable advantages over typical early-stage candidates. First, its ExpreS2 protein and AdaptVac cVLP virus platforms, have been validated in a large-scale Phase III trial via the ABNCoV2 COVID-19 vaccine. Second, ES2B-C001’s polyclonal approach targets multiple epitopes and when combined with the proven cVLP platform, may overcome issues of limited durability due to triggering a greater immune response. This reduces “me-too” competition risk and eases market access if marketing authorization is achieved.
Disclaimer: HC Andersen Capital receives payment from ExpreS2ion Biotech for a Digital IR/Corporate Visibility subscription agreement. /Claus Thestrup 1:30 PM 21-10-2024.
ExpreS2ion Biotech Holding
ExpreS2ion Biotech Holding är ett forsknings- och utvecklingsbaserat bolag med en patenterad plattform inom bioteknisk proteinproduktion. Bolaget har sin egen utvecklingspipeline av vaccinkandidater inom COVID-19, bröstcancer, influensa och malaria. Dessutom har bolaget intäkter från försäljning av tillverkningstjänster och plattformslicenser. Bolaget startade 2010 och har sin verksamhet i DTU Forskerpark i Hørsholm.
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