Xintela presents new preclinical results of XSTEM treatment on would healing and skin regeneration at cell therapy conference
Xintela is presenting today new preclinical data with the company’s stem cell product XSTEM® for wound healing and skin regeneration at the International Society for Cell & Gene Therapy (ISCT) Europe 2024, in Gothenburg. The results are presented both as a poster and as an oral presentation. XSTEM, which consists of allogeneic (donated) integrin α10β1-selected mesenchymal stem cells, is developed and manufactured by Xintela.
Xintela has previously communicated that XSTEM provided excellent healing of wounds in pigs and that the newly formed skin tissue closely resembled normal skin. The XSTEM treatment also showed less scarring (fibrosis) compared to control. Xintela is now presenting results from a second wound healing study in pigs, confirming high quality skin regeneration by XSTEM. Additionally, the new results demonstrated that XSTEM could be detected in the newly formed skin tissue after two weeks and that XSTEM differentiated into skin cells, keratinocytes, in cell cultures. This supports a regenerative capacity of XSTEM. The studies have been performed in collaboration with Professor Folke Sjöberg and his team at The Burn Center, Linköping University Hospital.
“We are really pleased to present the results from the preclinical wound healing studies at one of the leading conferences in the Cell and Gene Therapy space. The results on wound healing and skin regeneration are very impressive and strongly support the development of XSTEM for the treatment of chronic wounds”, says Xintela’s Chief Scientific Officer, Lucienne Vonk.