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Oncopeptides invited to present data on PDC platform efficacy in Acute Myeloid Leukemia at the American Society of Hematology meeting

Oncopeptides

Stockholm – November 20, 2024 – Oncopeptides AB (publ), a biotech company focused on difficult-to-treat cancers, today announces that an evaluation of the activity of two peptide drug conjugates (PDCs) developed by Oncopeptides in relapsed or refractory Acute Myeloid Leukemia has been accepted as a poster and will be presented at the 66th annual American Society of Hematology (ASH) Meeting and Exposition. The conference takes place in San Diego, California between December 7-10.

The study, conducted in collaboration with the Institute for Molecular Medicine Finland, FIMM, explores the preclinical effectiveness of two drugs based on Oncopeptides unique and proprietary PDC platform, melflufen and candidate drug OPDC3, for treating acute myeloid leukemia (AML) especially in cases where one of the standard treatments, venetoclax, has stopped working. Both drugs target cancer cells in a unique way and have shown promising results in laboratory tests with venetoclax-resistant AML preclinical models.

ASH is the world's largest professional hematologic society serving both clinicians and scientists around the world who are working to conquer blood diseases.

“The findings could support the development of new treatment options for AML patients who have limited alternatives based on the PDC platform,” says Caroline Heckman, PhD, Research Director, FIMM. “We are happy to have been selected to present our findings at ASH and look forward to the opportunity.”

Find more details about the abstract and presentation below. The abstract including key data has been published and is available through this link.
For more information about ASH Annual Meeting and Exposition, click here.

TitleEfficacy of the Peptide Drug Conjugates Melflufen and OPDC3 in Venetoclax Resistant Acute Myeloid Leukemia.
Publication Number1548
Presenting authorJuho Miettinen, PhD, senior researcher at FIMM.
ProgramOral and Poster Abstracts
TimeSaturday, December 7, 2024, 5:30 PM-7:30 PM
Session618. Acute Myeloid Leukemias: Biomarkers and Molecular Markers in Diagnosis and Prognosis: Poster I

For more information, please contact:
David Augustsson, Director of IR and Communications, Oncopeptides AB (publ)
E-mail: david.augustsson@oncopeptides.com
Cell phone: +46 76 229 38 68

About Oncopeptides
Oncopeptides is a biotech company focusing on research, development and commercialization of targeted therapies for difficult-to-treat cancers. The company uses its proprietary Peptide Drug Candidate platform (PDC) to develop compounds that rapidly and selectively deliver cytotoxic agents into cancer cells. 

Pepaxti® (melphalan flufenamide, also called melflufen) has been granted Marketing Authorization, in the European Union, the EEA-countries Iceland, Lichtenstein and Norway, as well as in the UK. Pepaxti is indicated in combination with dexamethasone for the treatment of adult patients with multiple myeloma who have received at least three prior lines of therapies, whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and one anti-CD38 monoclonal antibody, and who have demonstrated disease progression on or after the last therapy. For patients with a prior autologous stem cell transplantation, the time to progression should be at least 3 years from transplantation.

Oncopeptides is developing several new compounds based on its proprietary technology platforms and is listed on Nasdaq Stockholm with the ticker ONCO. For more information see: www.oncopeptides.com

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Oncopeptides invited to present data on PDC platform efficacy in Acute Myeloid Leukemia at the American Society of Hematology meeting